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Affected persons report that they hear voices, for example. Psychoses rank among the most severe mental illnesses. An international team of researchers under the guidance of the University of Bonn has now found out that after 24 hours of sleep deprivation in healthy patients, numerous symptoms were noted which are otherwise typically attributed to psychosis or schizophrenia.

In an initial run, the test subjects were to sleep normally in the laboratory. About one week later, they were kept awake all night with movies, conversation, games and brief walks.

On the following morning, subjects were each asked about their thoughts and feelings. In addition, subjects underwent a measurement known as prepulse inhibition.

Unselected information leads to chaos in the brain "Prepulse inhibition is a standard test to measure the filtering function of the brain," explains lead author Dr.

Nadine Petrovsky from Prof. In the experiment, a loud noise is heard via headphones. As a result, the test subjects experience a startle response, which is recorded with electrodes through the contraction of facial muscles.

If a weaker stimulus is emitted beforehand as a "prepulse", the startle response is lower. Filters separate what is important from what is not important and prevent sensory overload," says Dr.

In our subjects, this filtering function of the brain was significantly reduced following a sleepless night. Accordingly, their sense of time and sense of smell were altered and mental leaps were reported.

Many of those who spent the night even had the impression of being able to read thoughts or notice altered body perception.

Sleep deprivation as a model system for mental illnesses The scientists see an important potential application for their results in research for drugs to treat psychoses.

However, these convey the symptoms of psychoses in only a very limited manner," says Prof. Sleep deprivation may be a much better model system because the subjective symptoms and the objectively measured filter disorder are far more akin to mental illnesses.

Of course, the sleep deprivation model is not harmful: There is also a need for research with regard to persons who regularly have to work at night.

Sleep deprivation disrupts prepulse inhibition and induces psychosis-like symptoms in healthy humans, The Journal of Neuroscience, DOI: Contact Electronic Directory Locations.

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